Cellular Mechanotransduction Diverse Perspectives from Molecules to Biology Diagrams Living cells and tissues experience physical forces and chemical stimuli in a human body. The process of converting mechanical forces into biochemical activities and gene expression is mechanochemical transduction or mechanotransduction. Significant
Mechanotransduction is the ability of a cell to sense mechanical cues from its microenvironment and convert them into biochemical signals to elicit adaptive transcriptional and other cellular responses. Here, we describe recent advances in the field of mechanical regulation of transcription, highlight mechanical regulation of the epigenome as a key novel aspect of mechanotransduction, and
Mechanisms of mechanotransduction and physiological roles of PIEZO ... Biology Diagrams
Since the main annotation for YAP/TAZ transcription targets lies within the proliferation category, the activity of Hippo effectors in the nucleus has been historically associated with cell growth and tumor spreading (Zanconato et al., 2015), while our group and others lately proved that the mechanotransduction role of YAP is to be ascribed to
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism.
Mechanotransduction: from the cell surface to the nucleus via RhoA ... Biology Diagrams
The mechanically activated cation channels PIEZO1 and PIEZO2 are crucial for mechanotransduction processes in mammals. This Review discusses the structural design and gating dynamics of PIEZO RhoA signalling in fibrosis. A positive feed-forward cycle is illustrated. Transforming growth factor-beta (TGFβ) is released in response to tissue wounding. Severing the LINC complex, or complete removal of the nucleus, alter a cell's mechanotransduction. Much of the change may be due to reduced RhoA activity. The reason why RhoA activity
